FBPA PET in boron neutron capture therapy for cancer: prediction of 10B concentration in the tumor and normal tissue in a rat xenograft model
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FBPA PET in boron neutron capture therapy for cancer: prediction of 10B concentration in the tumor and normal tissue in a rat xenograft model
BACKGROUND Boron neutron capture therapy (BNCT) is a molecular radiation treatment based on the (10)B (n, α) (7)Li nuclear reaction in cancer cells, in which delivery of (10)B by 4-borono-phenylalanine conjugated with fructose (BPA-fr) to the cancer cells is of critical importance. The PET tracer 4-borono-2-(18) F-fluoro-phenylalanine (FBPA) has been used to predict the accumulation of BPA-fr b...
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چکیده ندارد.
15 صفحه اولThe Anti-Proliferative Effect of Boron Neutron Capture Therapy in a Prostate Cancer Xenograft Model
PURPOSE Boron neutron capture therapy (BNCT) is a selective radiation treatment for tumors that preferentially accumulate drugs carrying the stable boron isotope, 10B. BNCT has been evaluated clinically as an alternative to conventional radiation therapy for the treatment of brain tumors, and more recently, recurrent advanced head and neck cancer. Here we investigated the effect of BNCT on pros...
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Background: Boron neutron capture therapy (BNCT) is a binary radiotherapy combining biochemical targeting with neutron irradiation. However, monitoring the boron distribution is a fundamental problem in BNCT. Prompt gamma rays emitted by boron capture reaction can be used to address the issue. Materials and Methods: The general-purpose Monte Carlo toolkits Geant4 and MCNP were used for the simu...
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ژورنال
عنوان ژورنال: EJNMMI Research
سال: 2014
ISSN: 2191-219X
DOI: 10.1186/s13550-014-0070-2